Army pan-coronavirus vaccine

[woodman]

in a school setting, testing determines who will be qualified.
Who will get a degree.
on you tube, it is the most titillating and angering short films that get the most views.
The films that you present undergo pretty much the opposite of peer review.
Not only are the results taken down quickly for breaking rules, but we know from a recent whistle blower that fanning hate is very important for user engagement and clicks.

Obviously you are a very intelligent person, and you a have an extensive understanding of physics and astrophysics which any thinking person would respect. I recognize that, and many others recognize that. When we talk about "health care" it is as much outside your realm as it is for an engineer of any kind. From my point of view you are just as impressionable as any person who thinks their formal education gives them an advantage, and I would question that advantage for you on the subject of pathogens... My research shows me that as a group those with PHD's are the most zealous antivaxxers. I'm sure the algorithms that dictate your thought processes have led you in such a way that you would not discover that. I believe that peer review is another way of saying the material is compromised when the publication board of directors is controlled by an overarching agenda. Caution: There may be side effects to reading my posts. As far as UT goes as a video platform, I might think of it as a video library. Don't throw the baby out with the bath water! I would ask you to seriously consider who controls the mainstream media? UT is compromised to a large degree, although there are some youtubers that are pretty skilled at avoiding the censorship there while communicating an important message. I hope that you don't stay stuck in the weeds!

[woodman]

yes, this bias effect is not entertaining for long.
i have enjoyed a cross country trucking experience with bradley as full time co pilot.

Exactly who determines this "bias" you speak of? I wonder who the source is for spreading this Dunning Kruger phenomenon... Could it come from the same source that spreads trigger terms such as "conspiracy theorist" or "fringe lunatic" or "antivaxxer"? I heard the CIA is making public health decisions. I concur with what RFK Jr. says. Since when is the CIA in the health care business? LOL I want to share about conspiracy fact... How is that for a change? By the way, germ theory is just a theory...

Yes, Alf, we had a serendipitous time on our road trip in late October few years ago. The first 24 hours were the most challenging! We got along pretty well considering all the mishaps. It was a 17 day saga for me. I was hanging by a very thin rope a few times figuratively speaking. We both have good memories despite all the trials and tribulations, and you may have saved my life when I ran out of water on my hike...Just tellin' it how I see it... I'm glad I didn't try a portion of the PCT in Cali like we talked about, and you were an excellent driver, although we were hauling a bastard load, hauling it with an undersized 3/4 ton van when we needed a 1 ton minimum!!!

[mister_coffee]

There are approximately 1.3 million uniformed personnel in the US Military. There are about 20,000 of them refusing the vaccine, so the refusal rate is about 1.5 percent overall.

Given that the refusal rate in the general population is 20 to 30 percent, it seems like the US Military has less of a vaccine refusal problem than the general population.

[woodman]

"I have heard that one of the major challenges in testing this vaccine has been finding a population that isn't either already vaccinated or already infected."

They have had many opportunities to do post clinical studies to compare a vaxxed group to an unvaxxed group in a meaningful way, and this is with regards to all vaxxes before Covid, and the CDC seems to always compromise the integrity of the test by giving the "control" group some other cocktail of chemicals, but without the virus, but of course that muddies the waters in terms of doing a clear comparison. The authorities have consistently avoided doing a proper double blind study with a control group that only gets a placebo. With Covid, when the CDC abruptly required all those in the control group get vaxxed after 4 months or whatever that time period was because they claimed that the control group would be at increased risk over time, to me this is an effort to whitewash a proper test because they were worried about the outcome after a year or so. The fix is in, and the fox is guarding the henhouse. Pirates are in place locally as I observe, but there are sentries in place in great numbers waiting for the right moment to reveal what is really happening. Many are not willing to risk being ostracized.

[mister_coffee]

I have heard that one of the major challenges in testing this vaccine has been finding a population that isn't either already vaccinated or already infected.

Again, this technology is a big deal not just for covid and not just for vaccines. Nanotech medicine is probably our best bet both for a lot of serious endemic diseases, from influenza to malaria, but also is likely to be an extremely powerful tool for cancer treatments.

Nice for there to be reasons to be optimistic this dark winter...

[mister_coffee]

This is just plain cool:

https://www.army.mil/article/252890/ser ... t_strategy

SILVER SPRING, Md. – A series of recently published preclinical study results show that the Spike Ferritin Nanoparticle (SpFN) COVID-19 vaccine developed by researchers at the Walter Reed Army Institute of Research (WRAIR) not only elicits a potent immune response but may also provide broad protection against SARS-CoV-2 variants of concern as well as other coronaviruses.

Scientists in WRAIR’s Emerging Infectious Diseases Branch (EIDB) developed the SpFN nanoparticle vaccine, based on a ferritin platform, as part of a forward-thinking “pan-SARS” strategy that aims to address the current pandemic and acts as a first line of defense against variants of concern and similar viruses that could emerge in the future.

“The accelerating emergence of human coronaviruses throughout the past two decades and the rise of SARS-CoV-2 variants, including most recently Omicron, underscore the continued need for next-generation preemptive vaccines that confer broad protection against coronavirus diseases,” said Dr. Kayvon Modjarrad, Director of the Emerging Infectious Diseases Branch at WRAIR, co-inventor of the vaccine and the U.S. Army lead for SpFN. “Our strategy has been to develop a ‘pan-coronavirus’ vaccine technology that could potentially offer safe, effective and durable protection against multiple coronavirus strains and species.”

Pre-clinical studies published today in Science Translational Medicine indicate that the SpFN vaccine protects non-human primates from disease caused by the original strain of SARS-CoV-2 and induces highly-potent and broadly-neutralizing antibody responses against major SARS-CoV-2 variants of concern including the SARS-CoV-1 virus that emerged in 2002.

SpFN entered Phase 1 human trials in April 2021. Early analyses, expected to conclude this month, will provide insights into whether SpFN’s potency and breadth, as demonstrated in preclinical trials, will carry over into humans. The data will also allow researchers to compare SpFN’s immune profile to that of other COVID-19 vaccines already authorized for emergency use.

“This vaccine stands out in the COVID-19 vaccine landscape,” Modjarrad said. “The repetitive and ordered display of the coronavirus spike protein on a multi-faced nanoparticle may stimulate immunity in such a way as to translate into significantly broader protection.”

WRAIR developed a secondary candidate vaccine, a SARS-CoV-2 Spike Receptor-Binding Domain Ferritin Nanoparticle (RFN) vaccine, which targets a smaller part of the coronavirus Spike protein than the SpFN vaccine. Results from a study, published recently in the Proceedings of the National Academy of Sciences, show that this vaccine potentially offers similar protection against an array of SARS-CoV-2 variants and SARS-CoV-1.

“The RFN vaccine candidate is more compact and has some natural advantages as we try to increase the immune response against multiple coronaviruses using a single vaccine platform, so it is still under consideration as part of our pan-coronavirus vaccine development pipeline,” said WRAIR structural biologist and vaccine co-inventor, Dr. Gordon Joyce.

“The threat from COVID-19 continues as it evolves, and eventually there will be other emerging disease threats,” said Dr. Nelson Michael, Director of the Center for Infectious Diseases Research at WRAIR. “Our investment in developing a next generation vaccine is an important step towards getting ahead of COVID-19 and future disease threats.”

A SARS-CoV-2 Ferritin Nanoparticle Vaccine Elicits Protective Immune Responses in Nonhuman Primates

http://www.science.org/doi/10.1126/scitranslmed.abi5735

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

https://www.pnas.org/content/118/38/e2106433118

SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses

https://www.nature.com/articles/s41541-021-00414-4

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

https://www.nature.com/articles/s41541-021-00392-7

SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity

https://www.cell.com/cell-reports/fullt ... 21)01639-9

SARS-COV-2-Spike-Ferritin-Nanoparticle (SpFN) Vaccine With ALFQ Adjuvant for Prevention of COVID-19 in Healthy Adults

Clinical Trials.gov: https://clinicaltrials.gov/ct2/show/NCT04784767